The two meet in the first game of the round at Loftus Versfeld Stadium on Saturday afternoon at 15h30.
For Amakhosi, victory is essential if they want to stay in touch with the teams above them on the table. Steve Komphela’s men are currently third, a point behind leaders Bidvest Wits, who play Platinum Stars at Royal Bafokeng Stadium later on Saturday.
The Brazilians, meanwhile, are still finding their feet in the 2016/17 season after only playing three matches due to their successful CAF Champions League campaign.
Pitso Mosimane’s African champions are second bottom and lost in the Telkom Knockout in their last match, with Chiefs too bowing out of the same competition in their last competitive game.
Chiefs have a superior record from the two sides having won eight out of their last 20 league showdowns, with Sundowns winning six times and the other six games ending in draws.
In other fixtures over the weekend, SuperSport United can go top for a few hours should they beat Baroka FC at the New Peter Mokaba Stadium and other results go their way. Third-placed Matsatsantsa are level on 15 points with Chiefs.
In another mid-afternoon kick-off, Chippa United welcome fifth-placed Cape Town City to the Nelson Mandela Bay Stadium, before Orlando Pirates in sixth play their first league game since the 6-1 demolition by SuperSport when they take on Free State Stars in Soweto. Muhsin Ertugral has since been replaced as coach with interim boss Augusto Palacios.
There are two games on Saturday night with winless Ajax Cape Town up against Maritzburg United at Cape Town Stadium, while the leaders Wits will be playing Stars in Rustenburg.
On Sunday, another of the early-season pace-setters, fourth-placed Golden Arrows, travel to Makhulong Stadium to tackle Highlands Park, with the other game seeing coach-less Bloemfontein Celtic entertain Polokwane City at Dr. Molemela Stadium.
The full list of weekend fixtures are:
Saturday, November 19
15h30 – Mamelodi Sundowns v Kaizer Chiefs – Loftus Versfeld Stadium
15h30 – Baroka FC v SuperSport United – New Peter Mokaba Stadium
15h30 – Chippa United v Cape Town City – Nelson Mandela Bay Stadium
18h00 – Orlando Pirates v Free State Stars – Orlando Stadium
20h15 – Ajax Cape Town v Maritzburg Utd – Cape Town Stadium
20h15 – Platinum Stars v Bidvest Wits – Royal Bafokeng Stadium
Sunday, November 20
15h30 – Bloem Celtic v Polokwane City – Dr. Molemela Stadium
15h30 – Highlands Park v Golden Arrows – Makhulong Stadium-www.psl.co.za