Arsenal vs Manchester City Prediction, Preview, Odds: 21/9/2025

The Premier League serves up another heavyweight encounter this weekend as Arsenal host Manchester City at the Emirates. Both clubs arrive with injury concerns but also with strong ambitions, and the match promises to be more than just a tactical battle—it’s the continuation of one of English football’s fiercest modern rivalries.

Arsenal’s Injury Concerns and New-Look Squad

Mikel Arteta’s side will have to cope without several key attacking options. Forwards Kai Havertz and Gabriel Jesus, along with winger Bukayo Saka, are all unavailable, leaving Arsenal short in the final third. Defensive stalwart William Saliba is a doubt, as are Ben White and new signing Christian Nørgaard.

Against Liverpool last weekend, Arteta relied on a front three of Noni Madueke, Gabriel Martinelli, and Viktor Gyökeres. Summer arrival Eberechi Eze is also expected to grow into a larger role as the season progresses, offering creativity and versatility.

The Gunners oversaw a significant squad overhaul during the summer. Raheem Sterling, whose form disappointed last season, was moved on, along with defenders Jakub Kiwior (Porto) and Oleksandr Zinchenko (Nottingham Forest). Midfielders Thomas Partey (Villarreal) and Jorginho (Flamengo) also departed, as did full-back Takehiro Tomiyasu, who left as a free agent.

In terms of reinforcements, Arsenal strengthened in several key areas. Goalkeeper Kepa Arrizabalaga joined from Chelsea, defenders Mosquera (Valencia) and Piero Hincapié (Leverkusen) added depth at the back, while Martín Zubimendi (Real Sociedad) and Nørgaard (Brentford) bolstered the midfield. Offensively, Madueke (Chelsea) and Gyökeres (Sporting CP) were brought in to add fresh attacking options.

Manchester City’s Selection Problems

Pep Guardiola also faces a long list of absentees. Defenders Joško Gvardiol and John Stones, midfielders Phil Foden and Omar Marmoush, and new signing Rayan Cherki are all sidelined. Brazilian winger Savinho and full-back Rayan Aït-Nouri are also unavailable, while Bettinelli and Kalvin Phillips remain out of contention.

Despite these setbacks, City remain dangerous. Erling Haaland, fresh off scoring five goals for Norway during the international break, is expected to lead the line. He already has three goals in the Premier League this season. Midfield anchor Rodri, who collected the Ballon d’Or, is still finding his rhythm, while summer signing Tijjani Reijnders adds energy and creativity.

City made notable changes to their squad in the summer. Goalkeeper Ederson departed for Fenerbahçe, while Manuel Akanji, Kyle Walker, and Kevin De Bruyne all moved abroad. İlkay Gündoğan joined Galatasaray, Jack Grealish left the club, and James McAtee signed for Nottingham Forest. In response, City brought in goalkeeper Gianluigi Donnarumma (PSG), who could make his debut, alongside Trafford (Burnley), Reijnders (AC Milan), Nypan (Rosenborg), Cherki (Lyon), and Aït-Nouri (Wolves).

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Rivalry Fueled by History and Emotion

This fixture has grown into one of the Premier League’s most charged encounters. From Emmanuel Adebayor’s infamous celebration in 2008 to last season’s heated post-match scenes between Haaland and Gabriel, the rivalry has been fueled by emotion as much as competition.

Arsenal’s 5–1 demolition of City earlier this year still resonates, and the Gunners may carry the psychological advantage heading into this clash. Guardiola has accused Arsenal of using “dark arts” to disrupt his team, while Arteta has maintained calm defiance, setting the stage for another dramatic chapter.

Prediction

The game is likely to start cautiously, with both teams probing for openings. Arsenal’s midfield, led by Zubimendi, will look to dictate tempo and release Gyökeres to stretch City’s backline. Haaland will almost certainly test Arsenal’s defense, but with City missing key figures at both ends of the pitch, the Gunners’ home advantage could prove decisive.

A tight contest is expected, but Arsenal’s sharper cohesion and recent psychological edge suggest they may edge this one.

Predicted Score: Arsenal 2 – 1 Manchester City

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